Codeine is an opioid An opioid is any agent that binds to opioid receptors found in principally in the central nervous system and gastrointestinal tract. There are four broad classes of opioids: endogenous opioid peptides, produced in the body; opium alkaloids, such as morphine (the prototypical opioid) and codeine; semi-synthetic opioids such as heroin and oxycodone; and fully synthetic opioids such as pethidine and methadone that have structures unrelated to the opium alkaloids.

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An analgesic is any member of the diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs NSAID such as the salicylates, narcotic drugs such as morphine, and synthetic drugs with narcotic properties such as tramadol. Other classes of drugs not normally considered analgesics are used to treat neuropathic pain syndromes; these include tricyclic antidepressants and anticonvulsants. It is commonly marketed as the phosphate salt codeine phosphate. Codeine is an alkaloid found in opium.While codeine can be extracted from opium, most codeine is synthesized from morphine.